5'-THYMIDYLIC ACID DISODIUM SALT

PRODUCT IDENTIFICATION
CAS NO. 365-07-1 (Base)
33430-62-5 (Disodium)

5'-THYMIDYLIC ACID DISODIUM SALT
EINECS NO. 261-992-0, 251-518-0
FORMULA C10H13N2Na2O8P
MOL WT. 366.17

H.S. CODE

  

TOXICITY

 
DERIVATION

 
SYNONYMS dTMP disodium salt; TMP disodium salt
5'-Thymidylsäure, Dinatriumsalz; ácido 5'-timidílico, sal disódica; Acide thymidylique-5', sel disodique;  Thymidine-5'-monophosphoric acid  disodium salt;

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white powder
MELTING POINT

 
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS

 

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY

Stable under ordinary conditions. Hygroscopic.

GENERAL DESCRIPTION & APPLICATIONS
Ribose is a pentose (five-carbon sugar) that is a component of the ribonucleic acid (RNA), where it alternates with phosphate groups to form the 'back-bone' of the RNA polymer and binds to nitrogenous bases. Ribose phosphates are components of the nucleotide coenzymes and are utilized by microorganisms in the synthesis of the amino acid histidine. Its close relative, deoxyribose, is a constituent of deoxyribonucleic acid (DNA), where it alternates with phosphate groups to form the 'back-bone' of the DNA polymer and binds to nitrogenous bases. The presence of deoxyribose instead of ribose is one difference between DNA and RNA. Ribose has one more oxygen atom in its molecule than deoxyribose. Ribose has a five member ring composed of four carbon atoms and one oxygen. Hydroxyl groups are attached to three of the carbons. The other carbon and a hydroxyl group are attached to one of the carbon atoms adjacent to the oxygen. In deoxyribose, the carbon furthest from the attached carbon is stripped of the oxygen atom in what would be a hydroxyl group in ribose. The sugar (ribose or deoxyribose) molecules in the nucleic acid are all oriented in the same direction. Their carbon atoms are numbered: the 5' carbon atom is always on the side of the sugar molecule that faces the leading end, while the 3' carbon atom always faces the tail end. Nucleotide is the structural unit of a nucleic acid. A nucleotide consists of either a nitrogenous heterocyclic base (purine or pyrimidine) , a pentose sugar (ribose or deoxyribose) and a phosphate group attached at the 5' position on the sugar. A nucleoside consists of only a pentose sugar linked to a purine or pyrimidine base, without a phosphate group. Purine bases are Adenine, Guanine and Hypoxanthine (examples of purine nucleosides are Adenosine, 2'-Deoxyadenosine, Guanosine, 2'-Deoxyguanosine, Inosine, 2'-Deoxyinosine). Pyrimidine bases are Cytosine, Thymine, and Uracil (examples of pyrimidine nucleosides are Cytidine, 2'-Deoxyguanosine, 5-Methyluridine, 2'-Deoxy-5-Methyluridine, Uridine, 2'-Deoxyuridine). The nucleoside derivatives are involved in important functions in cellular metabolism and are used to synthesize enzyme inhibitors, antiviral agents, and anticancer agents.

 

Thymine is a pyrimidine base, occurring condensed with deoxyribose to form the nucleoside deoxythymidine in animal cells. Thymidine is significant because of its involvement in the biosynthesis of DNA and in the preservation and transfer of genetic information. It was thought that there is no thymine in ribonucleic acid (RNA); the thymine nucleotides contain only deoxyribose. However, It is now known that thymine, produced from uracil by post-transcriptional methylation, occurs as a rare base in rRNAs and tRNAs. When N1 is linked to the C1 of ribose, thymine forms a pyrimidine nucleoside called thymidines which are phosphorylated with from one to three phosphoric acid groups to form the three nucleotides; thymidine monophosphate(TMP), thymidine diphosphate(TDP), and thymidine triphosphate (TTP) respectively. TTP is involved in the formation of adenosine triphosphate (ATP) as a donator of phosphate groups to adenosine diphosphate (ADP).

  • Thymine: a pyrimidine base
  • Thymidine: a pyrimidine nucleoside
  • Thymidine Monophosphate (TMP, Thymidylic acid): a nucleotide, the 5'-phosphate of thymidine
  • Thymidine dDphosphate (TDP): a nucleotide, the 5'-pyrophosphate of thymidine
  • Thymidine Triphosphate (TTP): a nucleotide, the 5'-triphosphate of thymidine
  • Deoxythymidine Monophosphate (dTMP),   a nucleotide, the 5'-phosphate of deoxythymidine. (deoxy-, also called desoxy, is a prefix for the designation of compounds which contain one less atom of oxygen than the reference substance).
  • Deoxythymidine Diphosphate (dTDP),   a nucleotide, the 5'-pyrophosphate of deoxythymidine.
  • Deoxythymidine Triphosphate (dTTP),   a nucleotide, the 5'-triphosphate of deoxythymidine; a precursor in the synthesis of deoxyribonucleic acid.

Chemically modified nucleotides substituted or attached by special chemical groups or elements are studied and used to inactivate the normal biological operation in the living organism and the function of important enzymes.
SALES SPECIFICATION

APPEARANCE

 white powder
ASSAY (HPLC)

98.0% min
ABSORBANCES
0.64 - 0.66 (A250/A260) (pH 2)
0.71 - 0.73 (A280/A260)

HEAVY METALS

10ppm max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 36/36/38, Safety Phrases: 26-36